Targeting Human B-cell Malignancies through Ig Light Chain–Specific Cytotoxic T Lymphocytes
نویسندگان
چکیده
منابع مشابه
Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytes.
PURPOSE The variable regions of Ig (idiotype, Id) expressed by malignant B cells can be used as tumor-specific antigens that induce humoral and cellular immunity. However, epitopes derived from Id that stimulate human CD8(+) T-cell immunity are incompletely characterized. EXPERIMENTAL DESIGN The clonal Ig V(L) of human myeloma cell line U266 and five primary B-cell tumors were sequenced, and ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2011
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-11-0970